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2-hexyl-4-Pentynoic Acid (CAS 96017-59-3) is a valproic acid derivative that functions as a histone deacetylase (HDAC) inhibitor exhibiting an IC50 of 13 M HDACs regulate gene expression by removing acetyl groups from histones promoting chromatin condensation and transcriptional repression In cerebellar granule cells 2-hexyl-4-Pentynoic Acid increases acetylated histone H3 levels in a dose-dependent manner and enhances HSP70-1a/1b mRNA expression At 50 100 M it significantly elevates Ac-H3 levels beyond those achieved with valproic acid and provides complete protection against glutamate-induced cell death indicating its utility in neuroprotection and epigenetic research
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NSC 8751 (trans-2-Butenoic acid trans-Crotonic acid) is an unsaturated carboxylic acid compound containing -unsaturated carboxylic acid groups NSC 8751 is one of the important analogs for evaluating the safety of fragrance ingredients and is used to evaluate the toxicological properties of compounds with similar structures When NSC 8751 is applied to local lymph nodes a 50% concentration does not cause skin sensitization Structural analogs of NSC 8751 have been shown to be non-genotoxic trans-Crotonic acid can be used in the preparation of cosmetics and food additives[1][2]
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4-Pentenoic acid is a medium-chain unsaturated fatty acid 4-Pentenoic acid has hypoglycemic and fatty acid oxidation inhibitory activities 4-Pentenoic acid can affect blood glucose metabolism and energy metabolism through mechanisms such as inhibiting long-chain fatty acid oxidation reducing gluconeogenesis and promoting glucose utilization[1][2]
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Pentynoic acid STP ester sodium is a water-soluble click-chemistry reagent that contains a terminal propargyl (alkyne) group and an STP (sulfotetrafluorophenyl) activated ester. It is used to introduce alkyne handles onto biomolecules via amine-directed conjugation, enabling subsequent bioorthogonal click reactions.
Water-soluble alkyne-activated ester for bioconjugation.
Enables installation of terminal alkyne handles on proteins and peptides.
STP activated ester reacts efficiently with primary amines.
High reported purity suitable for sensitive biomolecular applications.
Stable when stored sealed and protected from moisture; compatible with low-temperature storage in solution.
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Angelic acid is a ferroptosis inducer that targets NRF2 degradation. It binds to the NRF2 protein, promoting its degradation through the ubiquitination-proteasome pathway. This action mitigates the inhibitory effect of NRF2 on oxidative stress and lipid peroxidation, leading to the induction of ferroptosis in tumor cells.
Purity: 99.20%
Molecular weight: 100.12
Molecular formula: C5H8O2
Appears as a white to off-white solid
Enhances accumulation of intracellular reactive oxygen species
Upregulates ferroptosis-related markers such as CHAC1 and PTGS2
Synergizes with other ferroptosis inducers to boost anti-tumor effects
Scavenges UVA-induced reactive oxygen species
Inhibits skin fibroblast senescence and prevents extracellular matrix degradation
Contributes to wound healing and has sedative activity
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An unsaturated fatty acid found in royal jelly produced from the hypopharyngeal and mandibular gland secretions of honeybees; isolated in conjunction with 10-HDA (Item No. 10976) and both demonstrate weak estrogenic activity, inhibiting binding of 17β-estradiol (Item No. ISO60155) to estrogen receptor β
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